Up front I’m going to admit that I am more than a bit peeved. In fact, I didn’t post last night because I had that metaphorical steam coming out of my ears and when I have that mental disposition I tend to not be so “nice and polite” or use “socially acceptable” language.
Flublogia’s newest blogger, Mr. Hammond of Immunocompetant, contributed an editorial to TWN and it has made its obligatory rounds to the rest of Flublogia.
WHO-LINKED CENTRE LAYS PATENT CLAIM ON BIRD FLU VIRUS
Published in SUNS #6539 dated 15 August 2008
Bogota, 14 Aug (Edward Hammond*) — In a development that is likely to raise more pressing questions about reform of the WHO Global Influenza Surveillance Network (GISN), an international patent application has surfaced in which the US Centres for Disease Control (CDC) and US National Institutes of Health claim ownership of Indonesian influenza genes.
A recent patent search has revealed that the CDC, which is a WHO collaborating centre, is applying for a patent for a new vaccine against influenza, particularly for bird flu (H5N1). The vaccine incorporates genes from a H5N1 strain isolated from an Indonesian human victim of bird flu in 2005.
The actual patent information:
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These vaccines target H5N1, H1, H3 and other subtypes of influenza and are designed to elicit neutralizing antibodies, as well as cellular immunity. The DNA vaccines express hemagglutinin (HA) or nucleoprotein (NP) proteins from influenza which are codon optimized and/or contain modifications to protease cleavage sites of HA which affect the normal function of the protein. Adenoviral constructs expressing the same inserts have been engineered for prime boost strategies. Protein-based vaccines based on protein production from insect or mammalian cells using foldon trimerization stabilization domains with or without cleavage sites to assist in purification of such proteins have been developed. Another embodiment of this invention is the work with HA pseudotyped lentiviral vectors which would be used to screen for neutralizing antibodies in patients and to screen for diagnostic and therapeutic antivirals such as monoclonal antibodies.
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| IPC: | C07K 14/435 (2006.01), C12N 15/86 (2006.01) | |||||||||||
| Applicants: | THE GOVERMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health,, Office of Technology Transfer, 6011 Executive Blvd., Suite 325, Rockvillle, Maryland 20852-3804 (US) (All Except US). THE GOVERMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Centers for Disease Control and Prevention, 4770 Biford Hwy (K79), Atlanta, Georgia 30333 (US) (All Except US). NABEL, Gray, J. [US/US]; 2520 30th Street, NW, Washington, District Of Columbia 20008 (US) (US Only). KONG, Wing-pui [US/US]; 13308 Copper Ridge Road, Germantown, Maryland 20874 (US) (US Only). YANG, Zhi-yong [CN/US]; 10004 Penfold CT, Potomac, Maryland 20874 (US) (US Only). TUMPEY, Terrence [US/US]; 970 Pebble Blend Drive, Grayson, Georgia 30017-1560 (US) (US Only). |
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| Inventors: | NABEL, Gray, J.; 2520 30th Street, NW, Washington, District Of Columbia 20008 (US). KONG, Wing-pui; 13308 Copper Ridge Road, Germantown, Maryland 20874 (US). YANG, Zhi-yong; 10004 Penfold CT, Potomac, Maryland 20874 (US). TUMPEY, Terrence; 970 Pebble Blend Drive, Grayson, Georgia 30017-1560 (US). |
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| Agent: | DELANEY, Karoline, A.; Knobbe, Martens, Olson & Bear, LLP, 2040 Main Street, 14th Floor, Irvine, California 92614 (US). | |||||||||||
| Priority Data: |
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| Title: | ANTIVIRAL AGENTS AND VACCINES AGAINST INFLUENZA |
| Abstract: |
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The US government nor the US CDC is not patenting the Indonesian strain of H5N1. They are, along with the researchers, filing for a patent on a DNA vaccine. That DNA vaccine incorporates a portion of the HA gene from an Indonesian human infection. And to be as plain as I can manage: It is not the portion of the gene being patented, it is the cytomegalovirus, Human T-lymphotropic virus, and A/Indonesia/05/05 H5N1 HA-MutA genetically manipulated construct that is being patented.
It is exactly the same principle as the Tamiflu most are familiar with. Tamiflu is derived, via a complicated process, from Star Anise. When Gilead patented what came to be known as Tamiflu it did not patent Star Anise, a major component, it patented the chemical composition, or recipe if you will, of oseltamivir phosphate.
I support my government’s granting scientific research, well, at least if its to benefit people such as cancer, AIDS, or Influenza research, with many other research areas that also fall into the category [as I define it]. I also support the fact that as financial sponsors of research the US Government [via the institutes involved] has a say in how the technology and findings are utilized. In the case of technology transfers it is the government that is ensuring developing nations have access, something that probably wouldn’t happen with regularity if left entirely within the control of private researchers or commercial enterprises.
Mr. Hammond, as a professed “independent researcher and an expert on patents and biological resources” , is either not such an “expert” or he deliberately chose an inflammatory and misleading title for his essay and knowingly made statements contained within that are out and out false.
For anyone interested in what the US government does with its patent interest I will offer this snippet:
US Department of Health and Human Services National Institutes of Health Office of Technology Transfer [link]
As part of the National Institutes of Health (NIH) mission to support biomedical research and reduce the burden of illness worldwide, the NIH Roadmap Initiative outlines the need to position the NIH to address the evolving public health challenges of the 21st Century and to enhance public-private partnerships. To support this mission, the NIH Office of Technology Transfer (OTT) is working to address global health challenges by facilitating the transfer of technologies to people around the world.
With many years of intellectual property management experience, OTT is ideally positioned to move technologies from the public sector to private industry in the U.S. and abroad. Indeed, out of the thousands of licenses OTT has executed to date, over 300 have been licensed to foreign companies. Approximately 200 products utilizing NIH technologies have been commercially marketed through various domestic and international public-private partnerships.
Through a comprehensive analysis of its portfolio and an on-going dialogue with regional, international, and private institutions to delineate the needs and capabilities of emerging economies, OTT has identified a niche of relevant technology transfer opportunities for diseases such as HIV/AIDS, pertussis, malaria, dengue, childhood diarrhea (rotavirus), meningitis, typhoid fever, cancer, and diabetes. OTT has already transferred such technologies or is currently negotiating license agreements with public and private institutions in India, Mexico, Brazil, China, Korea, Egypt, Argentina, and South Africa.
Mr. Hammond may be new to Flublogia but an early lesson in the “self-correcting” nature of the Cyber Flu Community may prove to be of benefit. Looking past rudeness and ill-mannered behavior is one thing, looking past deliberately misleading and inflammatory statements is an entirely different matter and one I do not suffer in silence. Not liking genetic engineering is something shared by many people, there are real issues to the practice and science, one need not bend reality and inflame readers to make legitimate points, if legitimate points exist. One only need stoop to that practice if there is nothing but hot air and vitriol supporting the claims and accusations.
SZ


As much as I bristle at Mr. Hammond’s misleading statements and the potential to do harm to the integrity of Flublogia and especially these fine agencies maligned in his report, I am more angered at these news media that lend platforms for these types of “drive by” reporting without due diligence on their part for accuracy thereof.
Let’s hope Mr. Hammond’s stay in Flublogia is a short one.
Hey Jay,
Thanks for the great comment and what a prescient one it turned out to be. I read a piece on Salon [via a google alert] today that moved me from “peeved” to outraged.
Serious bytes were devoted and they will be given the weight of serious bytes and few will realize they are underpinned with nothing substantive, and worse misleading deliberate falsehoods.
So, tell me… what else can you see in that crystal ball of yours?
why do CDC,NIH claim for patents at all ?
Aren’t they public, nonprofit organisations, payed from taxes ? Isn’t it their task to
encourage vaccine development by others rather than hindering
it with patents ? Will the money gained from these patents go back
to the taxpayers ?
I’ll stick to my guns. I think that SZ is the one that doesn’t know how to read a patent. Lord knows, I’ve read thousands.
If anything, I am embarrassed to say that I understated the scope of the claims, in particular Claim 1, which on close read is even more of a problem than I initially thought.
Bottom line: Yep, the US government is claiming Indonesian (and Thai and other) flu materials as its property. These are materials given to WHO for public health purposes, not proprietary claims.
Deal with it. Because we have to, in order to fix the GISN.
Oh wait, by the way:
What is my other agenda?
I hope you can enlighten me.
Mr. Hammond, I do not now, nor have I ever claimed to be an expert on patents or anything else for that matter. Generally I satisfy myself with being well informed. That stipulated to: the patent claim as filed:
Summary of the Invention This invention describes the development of plasmid DNA vaccines and plasmid
I honestly don’t know how much plainer the explanation can be made. These are *constructs* and not naturally occurring viral genes. With all deference to your expertise of course.
Might I also suggest a brief review of what a plasmid is and its functions in genetic *constructs*.
As to “other agenda” and you…
A simple review of your previous web incarnation revealed your “issues” with genetic engineering, obviously, something that is integral to this is current “scoop” of yours. This alone would place the two of us on opposite sides as I am an open supporter of much of the work on the genetic engineering front, as I have stated on my blog even before you showed up in Flublogia. You’ve also publicly registered your “issues” with the resurrection (and I presume study) of the original 1918 H1N1, something I supported and continue to support, and nothing new there either. We *must* study to learn. We must learn to be armed (ah, forgive the “GI Jane” phraseology) it just comes naturally to me.
how can they “claim” for something when they deny it ?
Maybe some formulation in the patent was
unfortunate and can be clarified/corrected